Artículos

Clinical and Molecular Comparative Study of Colorectal Cancer

2019-03-21T23:24:07+00:00

Clinical and Molecular Comparative Study of Colorectal Cancer Based on Age-of-onset and Tumor Location In Europe, colorectal cancer (CRC) is the third most common cancer in males, the second most common cancer in females, and the fourth most common cause of cancer-related deaths; worldwide, 1,360,000 new cases are diagnosed each year and it causes [...]

Clinical and Molecular Comparative Study of Colorectal Cancer2019-03-21T23:24:07+00:00

Comment on ‘Wild-type APC

2019-03-14T23:02:10+00:00

Comment on 'Wild-type APC prediction of poor prognosis in microsatellite-stable proximal colorectal cancer differs according to the age of onset' Taking as the starting point the work by Jorissen et al (2015), we have analysed the same aspects, but applying an age of onset criterion, and compared a total of 56 cases of EOCRC [...]

Comment on ‘Wild-type APC2019-03-14T23:02:10+00:00

New perspectives in Multiple Primary Colorectal Cancer

2019-03-14T16:22:34+00:00

We identify the features of multiple primary colorectal cancer (MPCC), synchronous colorectal cancer (SCRC) and metachronous colorectal cancer (MCRC), and distinguish between the cases that require a more extensive surgery and those where the parameters of SCRC might be important to prevent the development of MCRC. Full article: https://lnkd.in/eJBgh6N

New perspectives in Multiple Primary Colorectal Cancer2019-03-14T16:22:34+00:00

Hemorragia Digestiva baja por varices ectópicas sobre bridas

2019-03-14T16:24:05+00:00

La hipertensión portal ocasiona con frecuencia la aparición de derivaciones portosistémicas típicas como las varices esofágicas, y también, con mucha menos frecuencia, otras atípicas denominadas varices ectópicas. A pesar de su rareza, estas últimas pueden ser causa de hemorragia gastrointestinal grave. Un factor predisponente a su aparición son las bridas intraabdominales, en especial posquirúrgicas. [...]

Hemorragia Digestiva baja por varices ectópicas sobre bridas2019-03-14T16:24:05+00:00

Redefining synchronous colorectal cancers based on tumor clonality.

2019-03-14T22:33:01+00:00

To analyze the possible clonal origin of a part of Synchronous colorectal cancer (SCRC), we studied 104 paired-SCRCs from 52 consecutive patients without hereditary forms of CRC. We used a Single-Nucleotide Polymorphism array to characterize the genomic profiles, and subsequently used a statistical application to define them according to clonality within the same individual. [...]

Redefining synchronous colorectal cancers based on tumor clonality.2019-03-14T22:33:01+00:00

Clinical and functional characterization of the CDH1

2019-03-19T23:55:34+00:00

Clinical and functional characterization of the CDH1 germline variant c.1679C>G in three unrelated families with hereditary diffuse gastric cancer Germline changes in the CDH1 tumor suppressor gene predispose to diffuse gastric cancer and lobular breast cancer. In carriers of deleterious germline CDH1 variants, prophylactic gastrectomy is recommended. In case of germline missense variants, it is [...]

Clinical and functional characterization of the CDH12019-03-19T23:55:34+00:00

Differential clinicopatho-logical and molecular features

2019-03-20T00:04:07+00:00

Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location BACKGROUND: Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC). RESULTS: Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance [...]

Differential clinicopatho-logical and molecular features2019-03-20T00:04:07+00:00

NOMO-1 gene is deleted in early-onset colorectal cancer

2019-03-14T16:41:41+00:00

To characterize clinical features of a recurrent alteration in 16p13.12-p13.11 in Colorectal Cancer (CRC), mainly in Early-onset subgroup (EOCRC), and to assess the status of NOMO1, a gene located in that region, we analyzed differential clinicopathological, familial and molecular features of CRC subsets with and without alterations in the 16p13.12-p13.11, in global and EOCRC [...]

NOMO-1 gene is deleted in early-onset colorectal cancer2019-03-14T16:41:41+00:00

Unsupervised Analysis of Array Comparative Genomic Hybridization Data

2019-03-20T00:20:15+00:00

Unsupervised Analysis of Array Comparative Genomic Hybridization Data from Early-Onset Colorectal Cancer Reveals Equivalence with Molecular Classification and Phenotypes AIM: To investigate whether chromosomal instability (CIN) is associated with tumor phenotypes and/or with global genomic status based on MSI (microsatellite instability) and CIMP (CpG island methylator phenotype) in early-onset colorectal cancer (EOCRC). METHODS: Taking as [...]

Unsupervised Analysis of Array Comparative Genomic Hybridization Data2019-03-20T00:20:15+00:00

Toward a Molecular Classification of Synchronous Colorectal Cancer

2019-04-04T21:49:25+00:00

Toward a Molecular Classification of Synchronous Colorectal Cancer: Clinical and Molecular Characterization BACKGROUND: Two or more primary colorectal tumors coexisting at the time of diagnosis are considered to be synchronous tumors. It is estimated that synchronous colorectal cancer (SCRC) only accounts for 1.1% to 8.1% of all colorectal cancers (CRCs), and its molecular basis [...]

Toward a Molecular Classification of Synchronous Colorectal Cancer2019-04-04T21:49:25+00:00